On Tuesday 19 and Wednesday 20 November 2024, healthcare professionals working in primary care from across the UK convened at ExCeL London for Guidelines Live, a 2-day conference focused on clinical guidance for general practice. Over the 2 days, 48 expert speakers shared practical advice for the primary care team in 68 presentations on topics ranging from infection to cardiovascular disease to women’s health to practice management. In this article, members of the Guidelines in Practice team discuss the sessions they found most insightful at this year’s event.